總共八組參加混雙比賽，僅柴原瑛菜列種子。
Giuliana Olmos (MEX) (1)/Marcelo Arevalo (ESA) (1)
vs 詹詠然 Latisha Chan (TPE)/Hugo Nys (MON)
詹皓晴 Hao-Ching Chan (TPE)/Michael Venus (NZL)
vs Jelena Ostapenko (LAT)/David Vega Hernandez (ESP)
Jaimee Fourlis (AUS) (WC)/Luke Saville (AUS) (WC)
vs Sania Mirza (IND)/Rohan Bopanna (IND)
Nicole Melichar-Martinez (USA)/Matwe Middelkoop (NED)
vs Ellen Perez (AUS) (6)/Harri Heliovaara (FIN) (6)
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Desirae Krawczyk (USA) (3)/Neal Skupski (GBR) (3)
vs Storm Hunter (AUS)/John Peers (AUS)
張帥 Shuai Zhang (CHN)/Robin Haase (NED)
vs Alana Parnaby (AUS) (WC)/Andrew Harris (AUS) (WC)
Kirsten Flipkens (BEL)/Edouard Roger-Vasselin (FRA)
vs Taylor Townsend (USA)/Jamie Murray (GBR)
Samantha Stosur (AUS) (WC)/Matthew Ebden (AUS) (WC)
vs Demi Schuurs (NED) (5)/Nikola Mektic (CRO) (5)
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Alicja Rosolska (POL) (7)/Jean-Julien Rojer (NED) (7)
vs Maddison Inglis (AUS) (WC)/Jason Kubler (AUS) (WC)
Anna Danilina (KAZ)/Aleksandr Nedovyesov (KAZ)
vs Kristina Mladenovic (FRA)/Juan Sebastian Cabal (COL)
Kimberly Birrell (AUS) (WC)/Rinky Hijikata (AUS) (WC)
vs Lyudmyla Kichenok (UKR)/Gonzalo Escobar (ECU)
Olivia Gadecki (AUS) (WC)/Marc Polmans (AUS) (WC)
vs 柴原瑛菜 Ena Shibahara (JPN) (4)/Wesley Koolhof (NED) (4)
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Gabriela Dabrowski (CAN) (8)/Max Purcell (AUS) (8)
vs 楊釗煊 Zhaoxuan Yang (CHN)/Jan Zielinski (POL)
Lizette Cabrera (AUS) (WC)/John-Patrick Smith (AUS) (WC)
vs Kimberley Zimmermann (BEL)/Tim Puetz (GER)
韓馨蘊 Xinyun Han (CHN) (WC)/張之臻 Zhizhen Zhang (CHN) (WC)
vs Luisa Stefani (BRA)/Rafael Matos (BRA)
Bethanie Mattek-Sands (USA)/Mate Pavic (CRO)
vs Jessica Pegula (USA) (2)/Austin Krajicek (USA) (2)