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隊伍在前者第一回合為主場
NED AFC Ajax v BSC Young Boys SUI
UKR FC Dynamo Kyiv v Villarreal CF ESP
ITA AS Roma v Shakhtar Donetsk UKR
GRE Olympiacos v Arsenal ENG
ENG Tottenham Hotspur v GNK Dinamo Zagreb CRO
ENG Manchester United v AC Milan ITA φ(._. )>φ(._. )>φ(._. )>φ(._. )>
CZE SK Slavia Prague v The Rangers FC SCO
ESP Granada CF v Molde FK NOR
2020-21歐霸聯16強淘汰賽預定於3/11及3/18舉行