論文在此
是preprint
https://www.biorxiv.org/content/10.1101/2022.10.13.512134v1.full.pdf
標題
Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1
Omicron
節錄一下重點
We generated chimeric recombinant SARS-CoV-2
encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2
isolate and compared this virus with the naturally circulating Omicron variant.
The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity,
mainly due to mutations in the receptor binding motif (RBM), yet unlike
naturally occurring Omicron, efficiently replicates in cell lines and
primary-like distal lung cells. In K18-hACE2 mice, while Omicron
causes mild, non-fatal infection, the Omicron S-carrying virus inflicts
severe disease with a mortality rate of 80%.
This indicates that while the vaccine escape of Omicron is
defined by mutations in S, major determinants of viral pathogenicity
reside outside of S.
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