剛剛略讀一下
鼠鼠沒打疫苗
所以致死率有80%
阿致死率太高的病毒也很難傳播
不利於演化
這實驗的重點就是造成重症的原因
非s蛋白所造成的
然後現在打疫苗的人這麼多了
不用過度害怕
對了第一作者名字有槓槓（-）
台灣人？
※ 引述《Tosca ( )》之銘言：
: 論文在此
: 是preprint
: https://www.biorxiv.org/content/10.1101/2022.10.13.512134v1.full.pdf
: 標題
: Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1
: Omicron
: 節錄一下重點
: We generated chimeric recombinant SARS-CoV-2
: encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2
: isolate and compared this virus with the naturally circulating Omicron variant.
: The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity,
: mainly due to mutations in the receptor binding motif (RBM), yet unlike
: naturally occurring Omicron, efficiently replicates in cell lines and
: primary-like distal lung cells. In K18-hACE2 mice, while Omicron
: causes mild, non-fatal infection, the Omicron S-carrying virus inflicts
: severe disease with a mortality rate of 80%.
: This indicates that while the vaccine escape of Omicron is
: defined by mutations in S, major determinants of viral pathogenicity
: reside outside of S.
: 翻譯沒有錢拿
: 阿伯我懶得翻譯了
: 大家自己去用google翻譯吧