備註請放最後面 違者新聞文章刪除
1.媒體來源:
https://medicalxpress.com/
2.記者署名:
由 南加州大學
by University of Southern California
3.完整新聞標題:
Falling for financial scams? It may signal early Alzheimer's disease
陷入金融詐騙？它可能是早期阿茲海默症的信號
4.完整新聞內文:
September 6, 2024
Falling for financial scams? It may signal early Alzheimer's disease
by University of Southern California
Older adults who are more vulnerable to financial scams may have brain
changes linked to a higher risk of Alzheimer's disease, according to a
first-of-its-kind study led by researchers at the USC Dornsife College of
Letters, Arts and Sciences.
Nearly 7 million Americans are living with Alzheimer's disease, the fifth
leading cause of death among those 65 and older. The disease will carry an
estimated $360 billion in health care costs this year alone, according to the
Alzheimer's Association.
陷入金融詐騙？它可能是早期阿茲海默症的信號
由 南加州大學
南加州大學多恩西夫文學、藝術與科學學院的研究人員領導的一項首次研究表明，更容易
遭受金融詐騙的老年人的大腦變化可能與患阿茲海默症的風險較高有關。
近 700 萬美國人患有阿茲海默症，這是 65 歲及以上老年人的第五大死因。據阿茲海默
症協會稱，光是今年，這種疾病就將帶來約 3,600 億美元的醫療費用。
Researchers led by Duke Han, professor of psychology and family medicine at
USC Dornsife, aimed to better understand the link between early Alzheimer's
disease and financial vulnerability by using high-powered MRI to examine the
brains of 97 study participants over age 50.
The scientists focused on the entorhinal cortex, a region that acts as a
relay station between the hippocampus—the brain's learning and memory center
—and the medial prefrontal cortex, which regulates emotion, motivation and
other cognitive functions. It is often the first region to show changes in
Alzheimer's disease, typically becoming thinner as the disease progresses.
由南加州大學多恩西夫分校心理學和家庭醫學教授 Duke Han 領導的研究人員旨在透過使
用高能MRI 檢查97 名50 歲以上研究參與者的大腦，更好地了解早期阿茲海默症與財務脆
弱性之間的關聯。
科學家們重點研究了內嗅皮層，該區域充當海馬體（大腦的學習和記憶中心）和內側前額
葉皮質之間的中繼站，調節情緒、動機和其他認知功能。它通常是阿茲海默症最先變化的
區域，通常隨著疾病的進展而變得更薄。
None of the study participants, age 52 to 83, showed clinical signs of
cognitive impairment, but all underwent MRI scans to measure the thickness of
their entorhinal cortex.
In addition, the researchers used a standardized tool called a Perceived
Financial Exploitation Vulnerability Scale (PFVS) to assess the participants'
financial awareness and their susceptibility to poor financial decisions,
which they term "financial exploitation vulnerability," or FEV.
年齡在 52 歲至 83 歲之間的研究參與者均未表現出認知障礙的臨床症狀，但所有人都接
受了 MRI 掃描以測量內嗅皮質的厚度。
此外，研究人員還使用了一種名為「感知金融剝削脆弱性量表」(PFVS) 的標準化工具來
評估參與者的財務意識及其對不良財務決策的敏感性，他們稱之為「金融剝削脆弱性”或
FEV。
By comparing the adults' FEV with the thickness of their entorhinal cortex,
Han and the team found a significant correlation: Those more vulnerable to
financial scams had a thinner entorhinal cortex.
This was especially true for participants age 70 and older. Previous research
has linked FEV to mild cognitive impairment, dementia and certain molecular
brain changes associated with Alzheimer's disease.
透過比較成年人的 FEV 與其內嗅皮質的厚度，Han 和團隊發現了顯著的相關性：那些更
容易受到金融詐騙的人的內嗅皮質較薄。
對於 70 歲及以上的參與者來說尤其如此。先前的研究已將 FEV1 與輕度認知障礙、癡呆
以及與阿茲海默症相關的某些分子大腦變化聯繫起來。
Han, who holds a joint appointment at Keck School of Medicine of USC, says
the findings provide crucial evidence supporting the idea that FEV could be a
new clinical tool for detecting cognitive changes in older adults—changes
that are often difficult to detect.
"Assessing financial vulnerability in older adults could help identify those
who are in the early stages of mild cognitive impairment or dementia,
including Alzheimer's disease," Han said. He added, however, that financial
vulnerability alone is not a definitive indicator of Alzheimer's disease or
other cognitive decline. "But assessing FEV could become part of a broader
risk profile," he said.
南加州大學凱克醫學院共同任命的 Han 表示，這些發現提供了重要的證據，支持 FEV 可
能成為檢測老年人認知變化的新臨床工具，而這些變化通常很難檢測到。
韓說： “評估老年人的財務脆弱性可以幫助識別那些處於輕度認知障礙或癡呆症（包括
阿茲海默症）早期階段的人。”然而，他補充說，僅財務脆弱性並不是阿茲海默症或其他
認知能力下降的明確指標。 「但評估 FEV 可能成為更廣泛風險狀況的一部分，」他說。
Han also noted several limitations of the study. Most participants were
older, white, highly educated women, making it difficult to generalize the
findings to a more diverse population. Additionally, while the study found a
link between entorhinal cortex thickness and FEV, it does not prove one.
Finally, the study does not include specific measures of Alzheimer's disease
pathology.
These limitations leave open the possibility that the relationship between
FEV and entorhinal cortex thinning could be explained by other factors.
Accordingly, Han said that more research, including long-term studies with
diverse populations, is needed before FEV can be considered a reliable
cognitive assessment tool.
韓也指出了該研究的一些限制。大多數參與者都是年齡較大、受過高等教育的白人女性，
因此很難將研究結果推廣到更多樣化的人群。此外，雖然研究發現內嗅皮質厚度與 FEV
之間存在聯繫，但並未證明這一點。最後，該研究不包括阿茲海默症病理學的具體測量。
這些限制使得 FEV 與內嗅皮質變薄之間的關係可以透過其他因素來解釋。因此，Han 表
示，在 FEV1 被視為可靠的認知評估工具之前，需要進行更多的研究，包括對不同族群的
長期研究。
The work is published in the journal Cerebral Cortex.
In addition to Han, study authors include Laura Fenton, Aaron Lim, Jenna
Axelrod and Daisy Noriega-Makarskyy of USC Dornsife; Lauren Salminen, Hussein
Yassine and Laura Mosqueda of Keck School of Medicine of USC; Gali
Weissberger of Israel's Bar-Ilan University; and Annie Nguyen of the
University of California, San Diego.
More information: Laura Fenton et al, Lower entorhinal cortex thickness is
associated with greater financial exploitation vulnerability in cognitively
unimpaired older adults, Cerebral Cortex (2024). DOI: 10.1093/cercor/bhae360
Journal information: Cerebral Cortex
這項工作發表在《大腦皮層》雜誌。
除了 Han 之外，研究作者還包括南加州大學多恩西夫分校的 Laura Fenton、Aaron Lim
、Jenna Axelrod 和 Daisy Noriega-Makarskyy；南加州大學凱克醫學院的 Lauren
Salminen、Hussein Yassine 和 Laura Mosqueda；以色列巴伊蘭大學的 Gali
Weissberger；和加州大學聖地牙哥分校的 Annie Nguyen。
更多資訊： Laura Fenton 等人，下內嗅皮質厚度與認知未受損的老年人更大的金融剝削
脆弱性相關，大腦皮質(2024)。DOI：10.1093/cercor/bhae360
期刊資訊： 大腦皮層
5.完整新聞連結 (或短網址)不可用YAHOO、LINE、MSN等轉載媒體:
https://reurl.cc/eyyQLL
6.備註:
今天很嗆吧？讓我們繼續檢討被害人謝謝。
https://imgur.com/jyOFGSB.jpg