Tulane study shows COVID-19’s lingering impacts on the brain
April 01, 2022
COVID-19 patients commonly report having headaches, confusion and other
neurological symptoms, but doctors don’t fully understand how the disease
targets the brain during infection.
covid 確診病患常有頭痛和其他神經系統症狀 但目前不完全瞭解病毒如何影響腦部
researchers at Tulane University have shown in detail how COVID-19 affects the
central nervous system, according to a new study published in Nature
Communications. The findings are the first comprehensive assessment of
neuropathology associated with SARS-CoV-2 infection in a nonhuman primate
model.
杜蘭大學研究人員展示 病毒影響中樞神經系統
這是首次在非人類靈長類 對 covid 病毒的神經病理學研究
發表在 Nature Communications 自然通訊期刊
The research team found severe brain inflammation and injury consistent with
reduced blood flow or oxygen to the brain, including neuron damage and death.
Microhemorrhages, or small bleeds in the brain, were also present.
發現嚴重的腦部發炎 往腦部血流量及氧氣輸送減少 包含神經元損傷和死亡
還有腦部的微量或少量出血
Surprisingly, these findings were seen in subjects that did not experience
severe respiratory disease from the virus.
驚訝的是 這些症狀在沒有嚴重呼吸道疾病的感染個體也有出現
“Because the subjects didn’t experience significant respiratory symptoms, no
one expected them to have the severity of disease that we found in the brain,
” Fischer said. “But the findings were distinct and profound, and undeniably
a result of the infection.”
感染個體沒有明顯呼吸道症狀 沒人預期腦部會有嚴重疾病
但這些發現是獨特的 不可否認是感染造成的
The findings are also consistent with autopsy studies of people who have died
of COVID-19, suggesting that nonhuman primates may serve as an appropriate
model, or proxy, for how humans experience the disease.
這些發現也與 covid 感染死亡的人類驗屍結果一致
顯示非人類靈長類可替代人類做為研究疾病模型
Neurological complications are often among the first symptoms of SARS-CoV-2
infection and can be the most severe and persistent. They also affect people
indiscriminately — all ages, with and without comorbidities, and with varying
degrees of disease severity.
神經系統症狀經常是第一個 covid 感染症狀 而且可能是最嚴重及持久的
而且它不挑人 年齡 有無共病症 輕重症 都有機會
Fischer hopes that this and future studies that investigate how SARS-CoV-2
affects the brain will contribute to the understanding and treatment of
patients suffering from the neurological consequences of COVID-19 and long
COVID.
Fischer 希望這項 covid 如何影響大腦的研究
對治療 covid 或 long covid 的神經系統疾病患者有幫助
來源：
https://news.tulane.edu/pr/tulane-study-shows-covid-19s-lingering-impacts-
brain
縮：
https://reurl.cc/pWzWKQ
論文：
https://www.nature.com/articles/s41467-022-29440-z