作者: TCMFINDER 2021-09-20 09:36:00
Abstract for Reference 6: Treatment of androgeneticalopecia in men6TIFinasteride in the treatment of men with frontal male pattern hair loss.AULeyden J, Dunlap F, Miller B, Winters P, Lebwohl M,Hecker D, Kraus S, Baldwin H, Shalita A, Draelos Z, Markou M, Thiboutot D, Rapaport M, Kang S, KellyT, Pariser D, Webster G, Hordinsky M, Rietschel R,Katz HI, Terranella L, Best S, Round E, Waldstreicher JSOJ Am Acad Dermatol. 1999;40(6 Pt 1):930.BACKGROUND: Finasteride, a specific inhibitor of type II 5alpha-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss.OBJECTIVE: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning.METHODS: This was a 1-year, double-blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review.RESULTS: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P<.001), as well as significant improvements in patient, investigator, and global photographicassessments. Efficacy was maintained or improved throughout the second year of the study. Finasteridewas generally well tolerated.CONCLUSION: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.ADUniversity of Pennsylvania School of Medicine, Philadelphia, USA.PMID10365924