All NSAIDs (including COX-2 inhibitors) have beenassociated with the development of acute kidney injury
https://reurl.cc/Dd2496https://reurl.cc/44zjaL藥物說明書:Renal prostaglandins may play a compensatory role in the maintenance of renal perfusion.Therefore, under conditions of compromised renalperfusion, administration of ARCOXIA may cause a reduction in prostaglandin formation and, secondarily, in renal blood flow, and thereby impair renalfunction.
https://pubmed.ncbi.nlm.nih.gov/31375416/