課程名稱︰分析化學丁
課程性質︰藥學系 醫學檢驗暨生物技術學系 必修
課程教師︰張煥宗
開課學院：理學院
開課系所︰化學系
考試日期（年月日）︰March 26, 2014
考試時限（分鐘）： 180分鐘
是否需發放獎勵金： 是
（如未明確表示，則不予發放）
試題 :
I. Comparison: (21 pts, 3 pts each)
(II) Buffer (9pts, 3 pts each):
(III) Acid and base: (15 pts; 6 pts for (1), 3 pts each for the rest)
(IV) Solubility (6 pts, 3 pts each)
(V) Absorption (21 pts, 3 pts each)
(VI) Calculation (9 pts, 3 pts each)
(VII) Standard addition method (9 pts, 3 pts each)
(VIII) Methodology (9 pts, 3 pts each)
(IX) Drug analysis (12 pts; 6 pts for (2), 3 pts for the rest)
Atorvastatin calcium (ATR) is mainly used for lowering blood cholesterol, while
ezetimibe (EZ) is used for the treatment of hypercholesterolemia and homozygous
sitosterolemia. Combination of ATR and EZ has the advantages of greater
therapeutic effects than with either drug alone. This combination causes
manifold reduction in LDL cholesterol level as compared to double dose of the
individual drug when used alone. Moreover, using of EZ with ATR enhances the
effects of statins at lower dose and reduces the associated side effects. The
UV-vis spectra for ATR (solid curve) and EZ (dotted curve) are shown below.
(1) Why is it advantageous of using a cmobination of the two drugs over
individual?
(2) Suggest a spectrometric method for the determination of the contents of the
two drugs in a pure mixture containing the two drugs.
(3) Is sample pretreatment necessary for the determination of the
concentrations of the two drugs in blood samples prior to the spectrometric
analysis? Why?